Drug metabolism and pharmacokinetics journals ncbi. Apr 30, 2014 drug metabolism involves the enzymatic conversion of therapeutically important chemical species to a new molecule inside the human body. Major location of drug metabolizing enzymes dysfunction can lead to impaired drug metabolismdecreased enzyme activity first pass metabolism effected may inc 24 x bioavailiability results in exaggerated pharmacological responses and adverse effects cardiac failure causes decreased blood flow to the liver. Drug metabolism is the chemical alteration of a drug by the body. In order to avoid latestage drug failure due to factors such as undesirable metabolic instability, toxic metabolites, drug drug interactions, and polymorphic metabolism, an enormous amount of effort has been expended by both the pharmaceutical industry and academia towards developing more powerful techniques and screening assays to identify the metabolic profiles and enzymes involved in drug. Drugmetabolizing enzymes mediate the metabolism of exogenous and endogenous substances. The primary objective of drug metabolism is to facilitate a drugs excretion by increasing its water solubility hydrophilicity. Current drug metabolism aims to cover all the latest and outstanding developments in drug metabolism and disposition. Drug metabolism and personalized therapy journal page at pubmed journals. Department of pharmacology virginia commonwealth university nida research. Division of basic research national institute on drug abuse nora chiang, ph. The general intention is to demonstrate that the metabolism of a drug is. From the department of pharmacology, vanderbilt university, nashville.
Genetic factors in drug metabolism american family physician. Drug metabolism and disposition will consider for publication manuscripts describing the results of original basic and clinical research that contribute significant and novel information on the metabolism, transport, and disposition of drugs, therapeutic macromolecules, environmental chemicals and in some instances endogenous compounds. August 2005 british journal of clinical pharmacology. In vitro ocular metabolism and bioactivation of ketoconazole in rat, rabbit and human. Metabolism biotransformation catalyzed by drugmetabolizing enzymes is a main defense mechanism of the body against xenobiotic threats, and regarded as a key determinant of pharmacokinetics and. By closing this message, you are consenting to our use of cookies. Medications development division national institute on drug abuse and billy r. The role of drug metabolism in the pharmaceutical industry analytical techniques in drug metabolism common experimental approaches and protocols drug metabolism in drug design and development emphasizes practical considerations such as the data needed, the experiments and analytical methods typically employed, and the interpretation and.
These processes determine the fate of a drug in the body. Manuscripts may describe in vitro and in vivo studies, theoretical and mechanistic work, regulation of drug metabolizing enzymes and drug transporters, genetic variability and polymorphisms, design of innovative tools for determining drug metabolism. Metabolism is an essential pharmacokinetic process, which renders lipid soluble and nonpolar. Articles considered for publication include studies in humans, animal and cellular models. Dmd presents important research in pharmacology and toxicology and is a valuable resource in drug design, drug metabolism, drug transport, expression of drug metabolizing enzymes and transporters, and regulation of drug metabolizing enzyme and transporter gene expression. Current issue journal of drug metabolism and toxicology. Most drugs lose their pharmacological activities mainly through. Drug metabolism and toxicology open access journals. Pdf in this article, aspects of absorption, distribution, metabolism, and excretion have been. Jun 01, 2008 pharmacokinetics is the study of the rate and extent of drug absorption, distribution, metabolism, and excretion. Home page journal of pharmacology and drug metabolism. Principles of nonlinear pharmacokinetics reza mehvar1 school of pharmacy, texas tech university health sciences center, 0 south coulter street, amarillo tx 79106 prologue nonlinear pharmacokinetics, as opposed to the more commonly observed linear pharmacokinetics, is a topic of discussion in most basic pharmacokinetics courses offered to.
Prodrug biochemical or chemical processes drug inactive active the definition of a prodrug is controversial in some circles. The term metabolism is commonly used probably because products of drug transformation are called metabolites. Wilkinson at the department of pharmacology, vanderbilt university, 542 robinson. In such cases, called firstorder elimination or kinetics, the metabolism rate of the drug is a constant fraction of the drug remaining in the body ie, the drug has a. The journal will accept original submissions in english on the understanding that the work is unpublished and is not being considered for publication elsewhere. Join accp online access to pharmacotherapy is included with accp membership. Read the latest articles of drug metabolism and pharmacokinetics at. They are therefore expressed also at other interfaces of the body with the environment such as the skin, lungs, and the kidney. The process may result in pharmacologically active, inactive, or toxic metabolite. The journal will accept original submissions in english on the understanding that the work is unpublished and is not being considered for publication. New journal jaccp is open for submissions we are happy to announce that accp will launch a new journal, journal of the american college of clinical pharmacy jaccp. Drug metabolism and clinical pharmacology learn about from the msd manuals medical professional version. Drug metabolic process involves two phases, the occurrence of which may vary from compound to compound. The enzymes involved in metabolism are present in many tissues but generally are more concentrated in the liver.
Recently, he identified and patented pharmacologically active metabolites of nexavar. Drug metabolism and disposition instructions to authors. The journal will accept original submissions in english on the. Some patients metabolize a drug so rapidly that therapeutically effective blood and tissue concentrations are not reached. Some drugs are chemically altered by the body metabolized.
Drug metabolism and pharmacokinetics dmpk is an official online journal of the japanese society for the study of xenobiotics jssx, and it replaces the jssxs former journal, xenobiotic metabolism and disposition. In order to avoid latestage drug failure due to factors such as undesirable metabolic instability, toxic metabolites, drugdrug interactions, and polymorphic metabolism, an enormous amount of effort has been expended by. The classical aspects of drug metabolism and disposition related to oral administration. Current drug metabolism is an essential journal for academic. Drug metabolism in drug design and development wiley online. More generally, xenobiotic metabolism from the greek xenos stranger and biotic related to living beings is the set of metabolic pathways that modify the chemical structure of xenobiotics, which are compounds foreign to an organisms normal. Drug metabolizing enzymes have evolved primarily as a defense against nonmedical chemicals taken up from the environment. Current drug metabolism is an essential journal for academic, clinical, government and. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Pharmacokinetics, metabolism, and pharmaceutics of drugs. Drug metabolism and pharmacokinetics journal page at pubmed journals. Drug metabolism and transport covers areas such as metabolism and transport of drugs, endogenously formed compounds, and environmental chemicals.
Pharmacokinetics, metabolism, and pharmaceutics of drugs of abuse editors. Drug metabolism in drug design and development wiley. Drug metabolism drugs merck manuals consumer version. Additionally we have included original research articles that were submitted to the journal over the past several months that use new models to study drug. Prodrug biochemical or chemical processes drug inactive active the definition of. Current drug metabolism is an essential journal for academic, clinical, government and pharmaceutical. Pdf drug metabolism and pharmacokinetics researchgate. Drug metabolism and pharmacokinetics journal elsevier. Use the link below to share a fulltext version of this article with your friends and colleagues. Pharmacokinetics, metabolism, and pharmaceutics of drugs of abuse. To learn about our use of cookies and how you can manage your cookie settings, please see our cookie policy. Oxidation, hydration, reduction, hydrolysis are different kind of reactions by which a drug is metabolized.
A forum for the commentary and analysis of current and emerging research approaches in the admetox arena, as well as metabolic, pharmacokinetic and toxicological issues relating to specific drugs, drugdrug interactions and drug classes. Prodrugs are inactive drugs that undergo a chemical or biochemical conversion to the active drug. The involved chemical modifications incidentally decrease or increase a drugs pharmacological activity andor halflife, the most extreme example being the metabolic activation of inactive prodrugs into active drugs, e. The contribution of these organs to drug metabolism is incompletely understood, but certainly. Drug in tissues metabolites distribution metabolism metabolism excretion absorption drug elimination distribution the process by which a drug is carried to sites of action throughout the body by the bloodstream.
Drug metabolism 2007 journal of pharmacy and pharmacology. Medicinal chemistry drug metabolism december 3rd, 2014 this section takes a look at drug metabolism specifically, it provides a short overview of the various common conjugation reactions involved in the metabolism of drugs. Liver is the major organ where a drug is metabolized. More generally, xenobiotic metabolism from the greek xenos stranger and biotic related to living beings is the set of metabolic pathways that modify the chemical structure of xenobiotics, which are compounds foreign to an organisms normal biochemistry, such as any drug. The general intention is to demonstrate that the metabolism of a drug is a primary concern throughout. In press, journal preproof, available online 16 april 2020. Because druginduced liver injury is one of the main reasons for drug development failures, it is important to perform drug toxicity screening in the early. The journal will publish papers across the spectrum of clinical pharmacy practice. Journal of pharmacology and drug metabolism jpdm is an international online open access journal which is dedicated to quarterly publishing of highquality papers that describe the most significant and cuttingedge research in novel insights of pharmacology and drug metabolism. Frontiers in pharmacology drug metabolism and transport. A forum for the commentary and analysis of current and emerging research approaches in the admetox arena, as well as metabolic, pharmacokinetic and toxicological issues relating to specific drugs, drug drug interactions and drug classes. Metabolism biotransformation catalyzed by drug metabolizing enzymes is a main defense mechanism of the body against xenobiotic threats, and regarded as a key determinant of pharmacokinetics and.
In this article, we discuss the basics of drug metabolism, the process. Official online journal of the japanese society for the. Drug metabolism and personalized therapy journals ncbi. Diabetes, obesity, hypertension, and cardiovascular diseases, with a. Current trends in drug metabolism and pharmacokinetics. Isbn 9789535100997, pdf isbn 9789535143543, published 20120222. Manuscripts may describe in vitro and in vivo studies, theoretical and mechanistic work, regulation of drug metabolizing enzymes and drug transporters, genetic variability and polymorphisms, design of innovative. Page 003 aft er 25 days of hcb administration, the rats were sacrifi ced under light ether aesthesia and blood samples were collected and the liver, kidney brain and intestine starting from the ligament of. Drug metabolism involves the enzymatic conversion of therapeutically important chemical species to a new molecule inside the human body. Metabolism or biotransformation the conversion from one chemical form of a substance to another. The substances that result from metabolism metabolites may be inactive, or they may be similar to or different from.
Current drug metabolism aims to cover all the latest and outstanding developments in drug metabolism, pharmacokinetics, and drug disposition. Drug metabolism and pharmacokinetics dmpk is an official online journal of the japanese society for the study of xenobiotics jssx, and it. Diabetes, obesity, hypertension, and cardiovascular diseases, with a special focus on inherited metabolic disorders. The metabolic ratios of mtx to 7ohmtx in plasma were constant during the first three months of the treatment of the patients for. Current issue journal of drug metabolism and toxicology displays the articles that are accepted and meant for publication during that month. Drug metabolism is the metabolic breakdown of drugs by living organisms, usually through specialized enzymatic systems. The journal will accept original submissions in english on the understanding that the work is unpublished and is not being. Emerging models of drug metabolism, transporters, and toxicity. Official online journal of the japanese society for the study.
725 1519 398 527 265 974 770 282 1142 859 1403 1385 842 1538 369 1123 1397 66 137 1189 477 516 1148 259 504 557 1202 1317 384 446 223 597 1129 363 1013 1540 149 439 584 673 984 1221 776 268 328 1319 1244 1015 812 115